Key Findings of Clinical Studies on Capsimax™ Capsicum Extract 

• Capsimax Pilot Clinical Clearly Establishes:
  • Tolerated well 
  • Positive Impact on Resting Metabolic Rate-the primary indicator of thermogenesis
  • Positive Indicators on Body Mass Index

Red Pepper and Capsaicinoids Clinically Proven 

• Capsaicinoids enhance thermogenesis
• Capsaicinoids increase energy expenditure
• Capsaicinoids enhance loss of calories
• Capsaicinoids help reduce caloric intake

• Yoshioka M, et al: Effects of red-pepper diet on the energy metabolism in men., J Nutr Sci Vitaminol 1995; 41: 647-656.
• Yoshioka M, et al: Effects of red pepper added to high-fat & high-carbohydrate meals on energy metabolism & substrate utilization in

Japanese women. BrJ Nutr 1998; 80: 503-510.

• Westerterp-Plantenga MS, et al: Oral and gastrointestinal satiety effects of capsaicine on food intake (Abstract). I

Int J Obes Relat Metab Disord 2004; 28(Suppl. 1):S35.

• Yoshioka M, et al: Maximum tolerable dose of red pepper decreases fat intake independently of spicy sensation in the mouth.

Br J Nutr 2004; 91: 991-995.  
 

Red Pepper and Capsaicinoids Clinically Proven 

• Capsaicinoids stimulates carbohydrate oxidation
• Capsaicinoids burns carbs
• Capsaicinoids stimulates fat oxidation
• Capsaicinoids burns fat

• Yoshioka M, et al: Effects of red-pepper diet on the energy metabolism in men.

J Nutr Sci Vitaminol 1995; 41: 647-656.

• Lim K, et al: Dietary red pepper ingestion increases carbohydrate oxidation at rest and during exercise in runners.

Med Sci Sports Exerc 1997; 29: 355-61.

Yoshioka M, et al: Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization

in Japanse women. BrJ Nutr 1998; 80: 503-510.

• Yoshioka M, et al: Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol 1995; 41: 647-656.

Red Pepper and Capsaicinoids 
Clinically Proven 

• Several International Studies demonstrate Weight Management Benefits in Humans
• Other Benefits:
  • Capsaicinoids reduce oxidative stress
  • Capsaicinoids have an antioxidant effect

• Kempaiah RK, et al: Influence of dietary curcumin, capsaicin and garlic on the antioxidant status of red blood cells and the liver

in high-fat-fed rats. Ann Nutr Metab. 2004 Sep-Oct;48(5):314-20. Epub 2004 Oct 1.

• Lee CY, et al: Short-term control of capsaicin on blood and oxidative stress of rats in vivo.

Phytother Res. 2003 May;17(5):454-8. Yoshioka M, Lim K, Kikuzato

                                                            Composition 

Capsimax™ Plus Blend Consists of:

• Capsicum Fruit Extract
• Caffeine Anhydrous
• Black Pepper Extract (Piperine)
• Niacin

Capsimax™ Plus Blend Clinical Study Design 

• Double-blind
• Randomized
• Placebo controlled
• Cross-over
• 25 subjects
• Study conducted at the University Oklahoma

Visit 1 

• Medical history
• Vital signs and weight
• Blood samples for laboratory analyses

Visits 2 and 3 

• Subjects took either Capismax™ Plus Blend or a placebo
• Served as their own control group, as half the group took Capismax™ Plus Blend on one day and then a placebo on a subsequent visit and the other half took the placebo first, then Capismax™ Plus Blend
• One week washout period between the two sessions

Visits 2 and 3 

Subjects were monitored during four periods as follows:

• a resting baseline period of 30 minutes prior to dosing
• a resting pre-exercise period of 60 minutes prior to exercise
• a 60 minute exercise period of moderate intensity (walking on treadmill)
• a resting 50 minute post-exercise period

Visit 4 

• Adverse events were recorded,
• Vital signs and weight were taken, and
• Blood samples for laboratory tests.

Background Variable 

• height (cm)
• weight (kg)
• heart rate (bpm)
• systolic blood pressure (mmHg)
• diastolic blood pressure (mmHg)

Outcome Variables 

• energy expenditure (Kcal/day)
• oxygen consumption (ml/kg/min)
• ventilation (L/Min)
• respiratory quotient
• rating of perceived exertion
• heart rate (bpm
• systolic blood pressure (mmHg)
• diastolic blood pressure (mmHg)

Capsimax™ Plus Blend Clinical Study Results 

• Upon baseline adjustment, statistical analysis indicated that when the subjects took Capsimax™ Plus, they burned
  • 3-times more calories before exercise,
  • 3% more calories during, and

·         12 times more calories for upto one hour after exercise compared to when they took placebo.

• This resulted in an average cumulative total of 278 more calories burned before, during and after exercise compared to placebo.

Other effects 

• Given the notable increase in energy expenditure following treatment with Capismax™ Plus Blend, it is not surprising that other metabolic parameters related to energy expenditure also rose.
• For instance, subjects taking Capismax™ Plus Blend also experienced 7.5% greater oxygen uptake during the exercise period and greater air flow through the lungs during the post-exercise period than those taking placebo.
• Despite the fact that Capismax™ Plus Blend takers were expending more energy than placebo takers, they did not perceive they were exerting themselves more.

What is 278 calories worth? 

• 1 hour and 20 minutes of walking at a moderate pace (2 mph)**
• 25 minutes of jogging (10 minute mile, 6 mph)**
• 1 hamburger
• 1 slice of cheese pizza
• 2 chocolate chip cookies
• 1/2 bagel with 1 T cream cheese

Consuming extra 278 calories per day can result in weight gain of over 25 pounds in one year!